The Taoiseach says the Mother and Baby Homes report highlights a "dark, difficult and shameful" chapter in Ireland's history.
The Commission of Investigation has found 9 thousand children died in the 18 institutions examined.
The 3,000 page report paints a stark picture of the thousands of women and children who were stigmatised and cruelly treated - which was supported and condoned by church and state.
56,000 unmarried mothers - ranging in age from 12 years old to women in their 40s - and 57,000 children passed through the 18 institutions examined between 1922 and 1998.
An "appalling" level of infant mortality is noted by the commission - 9,000 children died - around 15% of all those born in the homes.
Taoiseach Michael Martin says the scale of the suffering is hard to comprehend.
The Commission found very little evidence of physical abuse - but many women did suffer emotional abuse and were subject to derogatory remarks.
Following recommendations from the Commission, the government is to set up a redress scheme - and believes religious orders should make a significant contribution.
Legislation will also be brought forward so survivors can access their birth information.
The Taoiseach will make a state apology in the Dail tomorrow.