Ryan Johansson has been included in the Republic of Ireland Under-21 panel for friendlies against Switzerland, Australia and Denmark.
The highly-rated Sevilla player was recently granted clearance by FIFA to play for the national team. He has played at underage level for Luxembourg, but his mother is Irish.
Midfielder Johansson signed a six-year deal at Sevilla from Bayern Munich back in January.
Manager Jim Crawford has also named Getafe's John Joe Patrick Finn in his squad for the first time.
In all, there are seven newcomers in the party of 26.
Among them are Derby County's Festy Ebosele, Sheffield Wednesday's Ciaran Brennan, Lincoln City's Sean Roughan and in-form UCD striker Colm Whelan.
Bohemians pair Dawson Devoy and Andy Lyons and Bray goalkeeper Brian Maher are the other domestic players to get the nod.
The squad also includes Schalke's Dan Rose.
All matches will take place in the Spanish city of Marbella.
First up is Switzerland on Sunday (May 30th), before the Boys in Green take on Australia on Tuesday (June 1st) and then Denmark the following Saturday (June 5th).
The games will be seen as preparation for the 2023 European Championship qualifiers against Bosnia and Herzegovina and Luxembourg in September.
Republic of Ireland Under 21 squad:
Goalkeepers: Sam Blair (Norwich City), Brian Maher (Bray Wanderers), Dan Rose (Schalke 04)
Defenders: Ciaran Brennan (Sheffield Wednesday), Festy Ebosele (Derby County), Shane Flynn (Leicester City), Andy Lyons (Bohemians), Oisin McEntee (Newcastle United), Mark McGuinness (Arsenal), Lewis Richards (Wolves), Sean Roughan (Lincoln City).
Midfielders: John Joe Patrick Finn Benoa (Getafe), Luca Connell (Celtic), Conor Coventry (West Ham United), Dawson Devoy (Bohemians), Alex Gilbert (Brentford), Conor Grant (Rochdale), Ryan Johansson (Sevilla), Conor Noss (Borussia Mönchengladbach), Louie Watson (Derby County).
Forwards: Jonathan Afolabi (Celtic), Will Ferry (Southampton), Joshua ‘JJ’ Kayode (Rotherham United), Gavin Kilkenny (Bournemouth), Colm Whelan (UCD), Tyreik Wright (Aston Villa).