Planning permission has been lodged for more than 850 homes on Oscar Traynor Road in Coolock.
Glenveagh Living has partnered with the city council to deliver the units that will be a mix of social housing, cost-rental and affordable purchase.
The 17-hectare site, that sits near the entrance to the Port Tunnel, has long been earmarked for redevelopment but the plot has sat empty.
Public parks, allotments and a community centre are also planned.
If approved, work is expected to start on site at the end of next year, with the first houses completed by late 2024.
Lord Mayor of Dublin, Caroline Conroy, says it's a very significant moment for the Oscar Traynor Road project.
The entire development will be completed on a phased basis over four years.