Wales have been hit with a pair of withdrawals ahead of their upcoming trio of games.
Ryan Giggs' side play England in a friendly at Wembley on Thursday, before UEFA Nations League games with both the Republic of Ireland and Bulgaria.
Aaron Ramsey's been ruled out of the games as his club Juventus have placed all of their players in a bio-secure "bubble" and he'll definitely miss the friendly at Wembley.
Hal Robson-Kanu will miss all three games, with the West Brom striker ruled out due to a wrist injury.
Giggs is already without captain Gareth Bale, as the recently-returned Tottenham forward is still recovering from a knee injury.
It's hoped Ramsey will be released in time for Sunday's game at the Aviva Stadium. None of the Juve players are allowed to leave their 'bubble' by order of the local health authority, the Azienda Sanitaria Locale (ASL).
Two non-playing staff members at the Turin giants tested positive for COVID-19 at the weekend.
Juventus' latest Serie A game did not go ahead, after Napoli failed to show up for Sunday's game in Turin.
The ASL did not allow Napoli travel to Turin after Piotr Zielinski, Eljif Elmas and a member of staff tested positive for coronavirus.
However, the FIGC's Federal Prosecutor is believed to be investigating Napoli's adherence to the COVID-19 protocols.