Clery's has closed down with immediate effect.
Staff have been told it's been sold - for the second time in three years.
The iconic department store has been placed into liquidation, with bosses claiming the company hasn't got the money to pay next week's bills.
Unions say the news has come "out of the blue", and have asked for an emergency meeting.
Staff have been told not to come in tomorrow, and it's expected the Clerys name will disappear.