Dominic Thiem will not be able to defend his US Open men's singles title later this month.
The world no.6 has been forced out of the final Grand Slam of the year as he is yet to recover from a wrist injury.
Thiem hasn't played since retiring hurt in his last-16 match with Adrian Mannarino in Mallorca in June.
He subsequently withdrew from Wimbledon and the Olympic Games in Tokyo as a result.
With the US Open start date of August 30 rapidly approaching, Thiem has announced he will not be in New York.
"Unfortunately I had to take the decision to pull out from the US Open, and as well to finish my 2021 season" he informed his Instagram followers.
"My wrist got a little bit worse again, the last 6-7 weeks.
"I've been following the medical advice - my recovery was going really well but last week I hit a ball in training and started to feel some pain again.
"After some tests, they said that my wrist needs more time, so we've all agreed on being conservative to give my wrist some time to recover.
"I have a long career ahead of me and it's important to not take risks and rush back."
Thiem won his first Grand Slam in New York last year, coming from two-sets down to beat Novak Djokovic in the final.
He's just the latest player to confirm their absence from this year's US Open, with Roger Federer missing out because of knee surgery.