Planning permission has been granted to build the new National Maternity Hospital on the campus of St Vincent's Hospital.
The decision means work on the €300 million facility can now go ahead.
The 244-bed hospital will replace the existing maternity hospital at Holles St in the city centre.
Construction is expected to take more than four years, with the planning authority saying the impact on residents and traffic is not expected to be very significant.
Earlier controversy over the potential religious ownership of the facility resulted in the Sisters of Charity ending involvement with the St Vincent's Healthcare Group.
Ownership of the group is to be transferred to a newly-formed company with charitable status, which will simply be called 'St Vincent's'.