President Michael D Higgins has signed the Intoxicating Liquor (Amendment) Bill into law.
This clears the way for pubs, clubs and off licenses to open on Good Friday this year - ending a 90-year ban.
Many publicans had voiced frustrations over the restriction and called for it to be removed.
The Dáil debated the final stages of the bill last week.
Minister David Stanton said attitudes in Ireland have changed and this move will have a positive impact for the economy.
"Tourism makes a much greater contribution to the economy, especially during holiday times like Easter".
Many pub and restaurant owners have long called for a ban on them serving alcohol on Good Friday to be lifted.
During one call for the ban to be lifted, the Restaurants Association of Ireland pointed out that you can get a drink "within feet of the Vatican" on Good Friday.
Chief Executive Adrian Cummins called the ban "unacceptable and outdated" and warned that it had been damaging the tourism, restaurant and hospitality industries.
Last year, Senator David Norris said he wanted the ban to remain in place, arguing that Ireland "has a very, very, serious drinking problem, I think the last thing that we need is another day of drinking".