The Public Health Alcohol Bill has passed all stages in the Dáil this evening.
The legislation includes restrictions on advertising and sale of alcohol, such as minimum pricing.
It had faced strong opposition from the drinks industry, as well as from a number of independent and rural TDs.
Health Minister Simon Harris says tonight's outcome is significant for the country's health.
He argued: "This is the first time in the history of the State we have endeavoured to use public health legislation to address issues in relation to alcohol.
"It is therefore a groundbreaking measure."
Taoiseach Leo Varadkar suggested the new laws will 'save countless lives'.
Campaigners in favour of the bill also welcomed tonight's news: